Fibrinase (Noun)
Meaning
In the clotting of blood thrombin catalyzes factor XIII into its active form (fibrinase) which causes fibrin to form a stable clot.
Classification
Nouns denoting substances.
Examples
- Thrombin, an enzyme in the coagulation cascade, reacts with factor XIII to produce fibrinase, acting as a catalyst to form stable clots.
- Active fibrinase thus sets off a cross-linking reaction between the fibrin molecules, providing stability and mechanical strength to blood clots.
- Transglutaminase, also known as the active form fibrinase in the presence of thrombin, is critical for its function in stabilizing blood clots.
- Formation of the fibrin clot occurs upon fibrinase activation, allowing it to covalently link the fibrin beta- and gamma-chains together to build a stable clot.
- When factor XIII is transformed into fibrinase, it develops transamidating capabilities enabling cross-linking between adjacent fibrin molecules in forming stable blood clots.