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Devastate (Verb)

Cause extensive destruction or ruin utterly; "The enemy lay waste to the countryside after the invasion".

Verbs of size, temperature change, intensifying, etc..

Overwhelm or overpower; "He was devastated by his grief when his son died".

Verbs of size, temperature change, intensifying, etc..

The news of the natural disaster would devastate the entire town and leave many without homes.
Her parents divorce would devastate her and cause her to question the stability of relationships.
The company's sudden bankruptcy would devastate the employees who had invested their lives in the business.
The devastating diagnosis of an incurable illness would devastate John and change his life's focus.
Losing her scholarship would devastate Emily and shatter her dreams of pursuing a higher education.