Scleredema (Noun)
Meaning
A skin disease marked by hard edema of the tissue usually beginning in the face.
Classification
Nouns denoting natural processes.
Examples
- Scleredema occurs in about 14% of cases of insulin-dependent diabetes mellitus, especially in those with poor blood glucose control.
- The clinical manifestations of scleredema can vary significantly from one individual to another in terms of the extent and severity of symptoms.
- Scleredema can be associated with other diseases that affect connective tissue, such as dermatomyositis, and Hashimoto's thyroiditis.
- Upon physical examination, patients with scleredema often present with thickened indurated skin in the affected area and may have limited facial mobility.
- Histopathological findings characteristic of scleredema include thickened collagen bundles and deposits of mucopolysaccharides in the dermis.