Nucleolus Organiser (Noun)
Meaning
The particular part of a chromosome that is associated with a nucleolus after nuclear division.
Classification
Nouns denoting body parts.
Examples
- The nucleolus organiser is the specific chromosomal region responsible for nucleolar formation and ribosome biogenesis during cell division.
- After replication, the nucleolus organiser ensures proper segregation and subsequent nucleolar reassembly by facilitating interactions with various proteins and rRNA genes.
- Deletions or mutations within the nucleolus organiser can significantly impair ribosomal function, as nucleoli rely heavily on the expression of genes localised within this specific chromosomal domain.
- Throughout meiosis, each sister chromatid possesses its own nucleolus organiser, yet during early prophase their coalescence marks a critical event preceding nucleolar breakup.
- Certain non-histone proteins interact with nucleolar DNA sequences, crucial for nucleolus formation, selectively binding to the chromosomal region designated as the nucleolus organiser.