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Malignance (Noun)

(medicine) a malignant state; progressive and resistant to treatment and tending to cause death.

Nouns denoting natural processes.

Quality of being disposed to evil; intense ill will.

Nouns denoting attributes of people and objects.

The politician's malignance towards her opponents was evident in her scathing speeches and personal attacks.
His malignance towards the world was fueled by his own personal struggles and disappointments.
The villain's malignance was the driving force behind the plot to destroy the city.
The malignance in her eyes sent chills down the spines of those who crossed her path.
The malignance of the dictator's regime was marked by widespread human rights abuses and atrocities.