Hand-schuller-christian Disease (Noun)
Meaning
Inflammatory histiocytosis associated with disturbance of cholesterol metabolism; occurs chiefly in young children and is characterized by cystic defects of the skull and diabetes insipidus.
Classification
Nouns denoting natural processes.
Examples
- Hand-Schuller-Christian disease is a rare inflammatory histiocytosis with disturbance of cholesterol metabolism, particularly affecting the skull bones.
- The pathologic characteristics of Hand-Schuller-Christian disease include massive proliferation of histiocytes, foamy histiocytes, and cholesterol clefts within the lesions.
- Hand-Schuller-Christian disease primarily affects children before the age of 10, leading to various manifestations such as unexplained fever and skin rashes.
- Radiological study revealed the presence of cystic skull lesions in the patient, which were found to be associated with Hand-Schuller-Christian disease.
- Treatment options for patients with Hand-Schuller-Christian disease may involve corticosteroids and chemotherapy, which have shown effectiveness in managing disease progression.