Gamma Aminobutyric Acid (Noun)
Meaning
An amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter.
Classification
Nouns denoting substances.
Examples
- GABA is synthesized in the brain from glutamic acid and functions as an inhibitory neurotransmitter to slow down neuronal activity throughout the nervous system.
- Research suggests that GABA deficiency is involved in various neurological and psychiatric disorders such as anxiety, insomnia, and Parkinson's disease.
- In addition to its neurotransmitter role, GABA has also been implicated in muscle tone regulation, kidney function, and other peripheral effects.
- Administration of exogenous GABA does not result in an inhibitory response in humans because the amino acid is not capable of crossing the blood-brain barrier.
- Allosteric modulation of the GABA receptors in the brain by specific agents, such as benzodiazepines and barbiturates, results in enhancement of inhibitory synaptic activity and promotion of relaxation and sedation.