Factor Ix (Noun)
Meaning
Coagulation factor whose absence is associated with hemophilia B.
Classification
Nouns denoting substances.
Examples
- Hemophilia B is caused by mutations in the F9 gene, which encodes the coagulation factor_ix protein in the liver and secreted in the blood.
- The factor_ix gene is nearly 33 000 nucleotides in length, spans about 80 kilobases of genomic DNA and has 8 exons separated by 7 introns.
- Studies in severe hemophilia B have demonstrated the potential for the development of tolerance through exposure to small amounts of factor_ix over extended periods of time.
- Genetic variation of factor_ix among normal individuals does not predict its efficiency to rescue mice with the human F9 deficiency mutation from the fatal coagulopathy of haemophilia B.
- Several groups are investigating non-viral and viral approaches for liver gene transfer to increase expression of human factor_ix protein and rescue hemophilia B phenotypes in affected patients.