Epistasis (Noun)
Meaning
The suppression of a gene by the effect of an unrelated gene.
Classification
Nouns denoting natural processes.
Examples
- The presence of the gene variant in the BRCA2 gene can be masked by epistasis, resulting in a reduced penetrance of the associated cancer risk.
- Studies have shown that epistasis between the two genes can lead to the suppression of the phenotypic effects of one of the genes.
- The complex interactions between the genes involved in the disease made it difficult to identify the effects of epistasis on the expression of the trait.
- Epistasis between the regulatory gene and the structural gene can lead to the suppression of the downstream gene, resulting in a lack of the associated protein.
- The discovery of epistasis between the two genes provided a new explanation for the variability in the expression of the disease in different individuals.