Cyclooxygenase-1 (Noun)
Meaning
An enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys; "an unfortunate side effect of NSAIDs is that they block Cox-1".
Classification
Nouns denoting substances.
Examples
- Cyclooxygenase-1 is an enzyme that plays a crucial role in maintaining the health of the stomach lining by regulating the production of protective prostaglandins.
- The inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs can lead to gastrointestinal complications, including ulcers and bleeding.
- Research has shown that cyclooxygenase-1 is also involved in the regulation of kidney function, particularly in the maintenance of blood flow and glomerular filtration rate.
- The development of selective cyclooxygenase-2 inhibitors was aimed at reducing the gastrointestinal side effects associated with the inhibition of cyclooxygenase-1.
- Cyclooxygenase-1 is constitutively expressed in most tissues, including the stomach lining and kidneys, where it plays a housekeeping role in maintaining tissue homeostasis.