Angiotensin-converting Enzyme (Noun)
Meaning
Proteolytic enzyme that converts angiotensin I into angiotensin II.
Classification
Nouns denoting substances.
Examples
- The renin-angiotensin-aldosterone system and the kallikrein-kinin system have been recognized as major targets for the therapeutic effects of angiotensin-converting enzyme inhibitors.
- The reaction sequence begins with conversion of angiotensinogen to angiotensin I by renin, followed by conversion of angiotensin I to angiotensin II by angiotensin-converting enzyme.
- Aspartate-158 is positioned close to the active site of angiotensin-converting enzyme, suggesting that it might play a functional role in substrate recognition or catalysis.
- By blocking angiotensin-converting enzyme, captopril inhibits the conversion of angiotensin I to angiotensin II, which increases as a result of renin release stimulated by vasodilation.
- The D allele within the angiotensin-converting enzyme gene has been associated with increased serum levels of circulating angiotensin-converting enzyme and two-fold increased production of angiotensin II.