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Angiotensin-converting Enzyme (Noun)

Meaning

Proteolytic enzyme that converts angiotensin I into angiotensin II.

Classification

Nouns denoting substances.

Examples

  • The renin-angiotensin-aldosterone system and the kallikrein-kinin system have been recognized as major targets for the therapeutic effects of angiotensin-converting enzyme inhibitors.
  • The reaction sequence begins with conversion of angiotensinogen to angiotensin I by renin, followed by conversion of angiotensin I to angiotensin II by angiotensin-converting enzyme.
  • Aspartate-158 is positioned close to the active site of angiotensin-converting enzyme, suggesting that it might play a functional role in substrate recognition or catalysis.
  • By blocking angiotensin-converting enzyme, captopril inhibits the conversion of angiotensin I to angiotensin II, which increases as a result of renin release stimulated by vasodilation.
  • The D allele within the angiotensin-converting enzyme gene has been associated with increased serum levels of circulating angiotensin-converting enzyme and two-fold increased production of angiotensin II.

Synonyms

  • Angiotensin Converting Enzyme
  • ACE

Hypernyms

  • Proteolytic Enzyme
  • Protease
  • Proteinase
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