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Irregardless (Adverb)

Regardless; a combination of irrespective and regardless sometimes used humorously.

I'm going to the party irregardless of the fact that I have an early meeting the next morning.
The comedian's joke was funny irregardless of its poor taste and lack of sophistication.
She decided to go for a run irregardless of the heavy rain and strong winds outside.
The new policy will be implemented irregardless of the employees' objections and concerns.
The team will play the game irregardless of the star player's injury and uncertain participation.